A Juvenile Murine Heart Failure Model of Pressure Overload
نویسندگان
چکیده
منابع مشابه
Activation of adenosine A1 receptor attenuates cardiac hypertrophy and prevents heart failure in murine left ventricular pressure-overload model.
Sympathomimetic stimulation, angiotensin II, or endothelin-1 is considered to be an essential stimulus mediating ventricular hypertrophy. Adenosine is known to protect the heart from excessive catecholamine exposure, reduce production of endothelin-1, and attenuate the activation of the renin-angiotensin system. These findings suggest that adenosine may also attenuate myocardial hypertrophy. To...
متن کاملEvaluation of immunomodulatory biomarkers in a pressure overload model of heart failure.
STUDY OBJECTIVES To characterize the immunomodulatory response in a pressure overload model of heart failure, and to further validate this animal model of human heart failure. DESIGN Randomized, controlled, animal study. SETTING Large university research facility. ANIMALS Twenty-seven, male, Sprague-Dawley rats. INTERVENTION The rats underwent either aortic constriction or a sham proced...
متن کاملRescue of Pressure Overload-Induced Heart Failure by Estrogen Therapy.
BACKGROUND Estrogen pretreatment has been shown to attenuate the development of heart hypertrophy, but it is not known whether estrogen could also rescue heart failure (HF). Furthermore, the heart has all the machinery to locally biosynthesize estrogen via aromatase, but the role of local cardiac estrogen synthesis in HF has not yet been studied. Here we hypothesized that cardiac estrogen is re...
متن کاملProtective effect of resveratrol against pressure overload-induced heart failure
Transverse aortic constriction (TAC)-induced pressure overload (PO) causes adverse cardiac remodeling and dysfunction that progresses to heart failure (HF). The purpose of this study was to determine whether the potent antioxidant, resveratrol, significantly attenuates PO-induced HF in wild-type mice. Male C57BL6 mice were subjected to either sham or TAC surgery. One group of TAC mice was given...
متن کاملA pressure overload model to track the molecular biology of heart failure.
OBJECTIVES Pressure overload plays an important role in left ventricular remodelling and the development of heart failure. The underlying molecular mechanisms behind these processes are poorly understood at the myocyte level. To investigate this, we developed an ovine model of pressure overload-induced heart failure, in which serial left ventricular biopsies were obtained. METHODS Adult male ...
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ژورنال
عنوان ژورنال: Pediatric Cardiology
سال: 2010
ISSN: 0172-0643,1432-1971
DOI: 10.1007/s00246-010-9833-3